Topiramate-induced nephrolithiasis

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Topiramate-induced nephrolithiasis

Nephrolithiasis is a less common side effect of the antiepileptic drug topiramate. We report the case of a 3-year-old boy who presented to the emergency department with abdominal pain; examinations revealed a large calcification in the left kidney. Regular ultrasound examinations are recommended in children using topiramate.

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Topiramate-induced nephrolithiasis.

Topiramate is a recently developed antiepileptic medication that is becoming more widely prescribed because of its efficacy in treating refractory seizures. Urologists should be aware that this medication can cause metabolic acidosis in patients secondary to inhibition of carbonic anhydrase. In addition, a distal tubular acidification defect may result, thus impairing the normal compensatory dr...

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Topiramate is a broad-spectrum antiepileptic medication that is used as monotherapy or in combination with other medications to treat epilepsy in both adults and children. It is also indicated for migraine prophylaxis in adults. An off-label use of topiramate is as a mood stabilizer (with no associated weight gain) in rapid-cycling and mixed bipolar episodes. The mechanisms of action of topiram...

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ژورنال

عنوان ژورنال: Clinical Case Reports

سال: 2015

ISSN: 2050-0904

DOI: 10.1002/ccr3.275